Drug Discoveries: Translating them to disease management protocols for patients.
Ira Pastor ideaXme longevity and aging ambassador and founder of Bioquarkinterviews John LaMattina, Senior Partner PureTech Healthand former President of R&D Pfizer. They talk of drug discoveries and treatments and the process of translating them to disease management protocols for patients.
Ira Pastor comments:
On the last several shows, we have spent time on the different hierarchical levels of the aging process and diseases of aging — from the genome, to tissue level physiologic networks, to the microbiome, to the human organism’s interaction with its external micro-environment.
Translating drug discoveries
However, exciting as all these scientific disciplines are, it all boils down to one thing — proper translation of these discoveries towards registrational and commercializable interventions that clinicians can prescribe and patients can make part of their disease management protocols.
Today’s guest is an expert’s expert in translatable drug development.
Drug discoveries: Patient protocols at Pfizer
Dr. John LaMattina, PhD in organic chemistry, climbed the ladder of big pharma to become President of Pfizer’s global R&D organization, where he managed more than 13,000 scientists and professionals in the United States, Europe, and Asia.
He was responsible for many of its” blockbusters” including Lipitor, Viagra, Zoloft, Zithromax, Celebrex, Aricept, Diflucan, and Norvasc which turned Pfizer into the $50+ billion mega-pharma organization.
Drug discoveries and health tech at PureTech Health
After Pfizer he moved into the venture capital world as a senior partner at PureTech Health sitting on the board of many start-up and development phase companies in the biotech and health tech space
He’s the author of several books including “Drug Truths: Dispelling The Myths Of R&D” and the recently published “Devalued And Distrusted: Can The Pharmaceutical Industry Restore Its Broken Image?” — He is also a routine contributor to Forbes magazine.
In this interview we hear from Dr. LaMattina about drug discovery and the paths to disease management protocols for patients
About his background, how he became interested in science, in particular pharma. Furthermore, we hear of his journey to the top of one of the world’s largest drug companies.
Drug discoveries for rare disease and large populations
His thoughts on the future of blockbuster drugs versus personalized medicines and more targeted approaches for smaller patient populations, rare, orphan diseases.
His analysis of anti-aging medicine and how Alzheimers will be one of mankind’s key challenges as the average lifespan increases.
His opinion on FDA approval of non-traditional drug discoveries.
His call to action to combat obesity, the cause of major illnesses in humans. See CDC website reporting on obesity statistics in the USA.
Legislation for drug discoveries
His views on the legislative front and proper ways for speeding up access to development stage drug candidates for “no-option” dying patients.
Towards the end of the interview discover whom John LaMattina would like to meet and what he’d like to discover in journeying to the future.
Credits: Ira Pastor interview text and audio.
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